Angiofibroma of Soft Tissue on the Cheek: Diagnosis Confirmed by Gene Rearrangement in NCOA2.
نویسندگان
چکیده
Jin-Wook JEONG1, Michihiro KONO1*, Yoshie HASEGAWA-MURAKAMI1, Toru MOTOI2, Kenji YOKOTA1, Takaaki MATSUMOTO1, Kaori KAIBUCHI-ANDO1, Yoichi KATO3, Toyohiro TADA4 and Masashi AKIYAMA1 1Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, 2Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, 3Division of Dermatology, Okazaki City Hospital, Okazaki, and 4Division of Pathology, Toyokawa City Hospital, Toyokawa, Japan. *E-mail: [email protected] Accepted May 11, 2016; Epub ahead of print May 13, 2016
منابع مشابه
Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma
We present an angiofibroma of soft tissue with the karyotype 46,XY,t(4;5)(q24;q31),t(5;8;17)(p15;q13;q21)[8]/46,XY,t(1;14)(p31;q32)[2]/46,XY[3]. RNA‑sequencing showed that the t(4;5)(q24;q31) resulted in recombination of the genes TBCK on 4q24 and P4HA2 on 5q31.1 with generation of an in‑frame TBCK‑P4HA2 and the reciprocal but out‑of‑frame P4HA2‑TBCK fusion transcripts. The putative TBCK‑P4HA2 ...
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عنوان ژورنال:
- Acta dermato-venereologica
دوره 97 1 شماره
صفحات -
تاریخ انتشار 2017